Research & Development
Peptimmune’s research and development efforts focus on developing peptide and peptide copolymer therapeutics for the treatment of CNS and Autoimmune disorders.
The Company is using its DEEP™ Technology (Directed Expansion of Epitope Permutation) to design peptides and peptide copolymers for development as therapeutics, diagnostic kits, and as reagents for antibody generation.
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Target biology:
Peptimmune’s target biology focuses on MHC Class II molecules found on antigen presenting cells, monocytes, and B cells, which bind peptides and stimulate immune responses. Peptimmune designs peptides that can modulate the immune response for use as therapeutics or vaccine-focused applications, and also in the generation of specifically diverse antibody responses.
Core Expertise
- Process control and solid-phase manufacturing of peptides and copolymers
- Molecular fingerprinting of peptide copolymers
- Immunoassay and bioassay development
- Pharmacokinetics
What is a Copolymer?
- Variables
- Amino acid ratio at output — process dependent
- Primary polypeptide sequence
- Length of peptides
- Biological properties of each species
- Mixture of “declensional” polypeptides
- Common parameters
- Fixed number of amino acids
- Fixed amino acid ratio at input
- Molecular weight distribution
- Common parameters
